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XENICAL is a pill that is taken with meals and has been shown to reduce weight in considerably overweight people. Support you can't find in a pill alone. Xenical is a prescription medication that can help considerably overweight people lose weight and keep it off.. A generic version of Xenical. Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. Used as part of a diet plan to help you lose weight. Candidates for treatment with orlistat are patients who are obese with a body mass index (a measure of obesity) of more than 30 kg/m2.Xenical works by preventing fat from being digested, which in studies have shown to be very effective for people who, on a normal diet, have difficulties losing weight. The unabsorbed fat is excreted in the stool.Chemical Name: ORLISTAT (OR-li-stat) Xenical is used with a low-calorie diet to help you lose weight and to maintain your weight after weight loss. 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